Tuberculosis Epidemiology

 

Assay design for unambiguous identification and quantification of circulating pathogen-derived peptide biomarkers.

Shu Q, Liu S, Alonzi T, LaCourse SM, Singh DK, Bao D, Wamalwa D, Jiang L, Lyon CJ, John-Stewart G, Kaushal D, Goletti D, Hu T. Theranostics. 2022 Mar 21;12(6):2948-2962. doi: 10.7150/thno.70373. eCollection 2022.PMID: 35401822 

 

Interferon Gamma Release Assay and Tuberculin Skin Test Performance in Pregnant Women Living With and Without HIV.

Kaplan SR, Escudero JN, Mecha J, Richardson BA, Maleche-Obimbo E, Matemo D, Kinuthia J, John-Stewart GC, LaCourse SM. J Acquir Immune Defic Syndr. 2022 Jan 1;89(1):98-107. doi: 10.1097/QAI.0000000000002827.PMID: 34629414

 

Tuberculosis screening among ambulatory people living with HIV: a systematic review and individual participant data meta-analysis.

Dhana A, Hamada Y, Kengne AP, Kerkhoff AD, Rangaka MX, Kredo T, Baddeley A, Miller C, Singh S, Hanifa Y, Grant AD, Fielding K, Affolabi D, Merle CS, Wachinou AP, Yoon C, Cattamanchi A, Hoffmann CJ, Martinson N, Mbu ET, Sander MS, Balcha TT, Skogmar S, Reeve BWP, Theron G, Ndlangalavu G, Modi S, Cavanaugh J, Swindells S, Chaisson RE, Ahmad Khan F, Howard AA, Wood R, Thit SS, Kyi MM, Hanson J, Drain PK, Shapiro AE, Kufa T, Churchyard G, Nguyen DT, Graviss EA, Bjerrum S, Johansen IS, Gersh JK, Horne DJ, LaCourse SM, Al-Darraji HAA, Kamarulzaman A, Kempker RR, Tukvadze N, Barr DA, Meintjes G, Maartens G.Lancet Infect Dis. 2022 Apr;22(4):507-518. doi: 10.1016/S1473-3099(21)00387-X. Epub 2021 Nov 17.PMID: 34800394 

 

CRISPR detection of circulating cell-free Mycobacterium tuberculosis DNA in adults and children, including children with HIV: a molecular diagnostics study.

Huang Z, LaCourse SM, Kay AW, Stern J, Escudero JN, Youngquist BM, Zheng W, Vambe D, Dlamini M, Mtetwa G, Cranmer LM, Njuguna I, Wamalwa DC, Maleche-Obimbo E, Catanzaro DG, Lyon CJ, John-Stewart G, DiNardo A, Mandalakas AM, Ning B, Hu TY.Lancet Microbe. 2022 Jul;3(7):e482-e492. doi: 10.1016/S2666-5247(22)00087-8. Epub 2022 May 31.PMID: 35659882 

 

Isoniazid preventive therapy and TB transcriptional signatures in people with HIV.

Valinetz ED, Matemo D, Gersh JK, Joudeh LL, Mendelsohn SC, Scriba TJ, Hatherill M, Kinuthia J, Wald A, Cangelosi GA, Barnabas RV, Hawn TR, Horne DJ.AIDS. 2022 May 24. doi: 10.1097/QAD.0000000000003262. Online ahead of print.PMID: 35608118

 

A CD4+ TNF+ monofunctional memory T-cell response to BCG vaccination is associated with Mycobacterium tuberculosis infection in infants exposed to HIV.

Warr AJ, Anterasian C, Shah JA, De Rosa SC, Nguyen FK, Maleche-Obimbo E, Cranmer LM, Matemo D, Mecha J, Kinuthia J, LaCourse SM, John-Stewart GC, Hawn TR.EBioMedicine. 2022 Jun;80:104023. doi: 10.1016/j.ebiom.2022.104023. Epub 2022 May 6.PMID: 35533496 


TB Immunology

 

Mycobacterium tuberculosis infection, immune activation, and risk of HIV acquisition.

Bender Ignacio RA, Long J, Saha A, Nguyen FK, Joudeh L, Valinetz E, Mendelsohn SC, Scriba TJ, Hatherill M, Janes H, Churchyard G, Buchbinder S, Duerr A, Shah JA, Hawn TR. PLoS One. 2022 May 3;17(5): e0267729. doi: 10.1371/journal.pone.0267729. eCollection 2022.PMID: 35503767 Free PMC article.

 

Durable Expansion of TCR-δ Meta-Clonotypes After BCG Revaccination in Humans.

James CA, Yu KKQ, Mayer-Blackwell K, Fiore-Gartland A, Smith MT, Layton ED, Johnson JL, Hanekom WA, Scriba TJ, Seshadri C. Front Immunol. 2022 Mar 30; 13:834757. doi: 10.3389/fimmu.2022.834757. eCollection 2022.PMID: 35432299 Clinical Trial.


It Takes a Village: The Multifaceted Immune Response to Mycobacterium tuberculosis Infection and Vaccine-Induced Immunity.

Larsen SE, Williams BD, Rais M, Coler RN, Baldwin SL. Front Immunol. 2022 Mar 10;13:840225. doi: 10.3389/fimmu.2022.840225. eCollection 2022.PMID: 35359957  Review.

 

Resistance to Mycobacterium tuberculosis infection among highly TB exposed South African gold miners.

Chihota VN, Ntshiqa T, Maenetje P, Mansukhani R, Velen K, Hawn TR, Wallis R, Grant AD, Churchyard GJ, Fielding K. PLoS One. 2022 Mar 18;17(3):e0265036. doi: 10.1371/journal.pone.0265036. eCollection 2022.PMID: 35302992

 

REL and BHLHE40 Variants Are Associated with IL-12 and IL-10 Responses and Tuberculosis Risk.

Shah JA, Warr AJ, Graustein AD, Saha A, Dunstan SJ, Thuong NTT, Thwaites GE, Caws M, Thai PVK, Bang ND, Chau TTH, Khor CC, Li Z, Hibberd M, Chang X, Nguyen FK, Hernandez CA, Jones MA, Sassetti CM, Fitzgerald KA, Musvosvi M, Gela A, Hanekom WA, Hatherill M, Scriba TJ, Hawn TR. J Immunol. 2022 Mar 15;208(6):1352-1361. doi: 10.4049/jimmunol.2100671. Epub 2022 Feb 25. PMID: 35217585

 

Effects of BCG vaccination on donor unrestricted T cells in two prospective cohort studies.

Gela A, Murphy M, Rodo M, Hadley K, Hanekom WA, Boom WH, Johnson JL, Hoft DF, Joosten SA, Ottenhoff THM, Suliman S, Moody DB, Lewinsohn DM, Hatherill M, Seshadri C, Nemes E, Scriba TJ, Briel L, Veldtsman H, Khomba N, Pienaar B, Africa H, Steyn M; Delayed BCG Study Team. EBioMedicine. 2022 Feb; 76:103839. doi: 10.1016/j.ebiom.2022.103839. Epub 2022 Feb 8. PMID: 35149285 

 

The Tuberculous Granuloma and Preexisting Immunity.

Cohen SB, Gern BH, Urdahl KB. Annu Rev Immunol. 2022 Apr 26;40:589-614. doi: 10.1146/annurev-immunol-093019-125148. Epub 2022 Feb 7. PMID: 35130029 Review.

 

Editorial: Exploring Immune Variability in Susceptibility to Tuberculosis Infection in Humans.

Seshadri C, Sutherland JS, Lindestam Arlehamn CS, Burel JG. Front Immunol. 2022 Jan 7;12:830920. doi: 10.3389/fimmu.2021.830920. eCollection 2021.PMID: 35069606 


CD4 and CD8 co-receptors modulate functional avidity of CD1b-restricted T cells.

James CA, Xu Y, Aguilar MS, Jing L, Layton ED, Gilleron M, Minnaard AJ, Scriba TJ, Day CL, Warren EH, Koelle DM, Seshadri C. Nat Commun. 2022 Jan 10;13(1):78. doi: 10.1038/s41467-021-27764-w.PMID: 35013257 

 

Novel HLA associations with outcomes of Mycobacterium tuberculosis exposure and sarcoidosis in individuals of African ancestry using nearest-neighbor feature selection.

Dawkins BA, Garman L, Cejda N, Pezant N, Rasmussen A, Rybicki BA, Levin AM, Benchek P, Seshadri C, Mayanja-Kizza H, Iannuzzi MC, Stein CM, Montgomery CG.Genet Epidemiol. 2022 Jun 14. doi: 10.1002/gepi.22490. Online ahead of print.PMID: 35702824

 

Cascade Immune Mechanisms of Protection against Mycobacterium tuberculosis (IMPAc-TB): study protocol for the Household Contact Study in the Western Cape, South Africa.

Hiemstra AM, MacDonald CE, van Rensburg IC, Stanley K, Maasdorp E, Mc Anda S, Tönsing S, Shaw JA, Tromp G, van der Spuy GD, Urdahl KB, Lewinsohn DM, Kuivaniemi H, Du Plessis N, Malherbe ST, Walzl G.BMC Infect Dis. 2022 Apr 15;22(1):381. doi: 10.1186/s12879-022-07349-8.PMID: 35428268 

 

Cumulative Mtb infection incidence (measured primarily by TST) among infants with HIV exposure: observational follow-up of an isoniazid prophylaxis trial.

LaCourse SM, Escudero JN, Mecha J, Warr AJ, Richardson BA, Carimo N, Cranmer LM, Maleche-Obimbo E, Matemo D, Kinuthia J, Hawn TR, John-Stewart G.Clin Infect Dis. 2022 May 24:ciac393. doi: 10.1093/cid/ciac393. Online ahead of print.PMID: 35607710

 

Mycobacterium tuberculosis-Specific T-Cell Responses Are Impaired During Late Pregnancy With Elevated Biomarkers of Tuberculosis Risk Postpartum.

Saha A, Escuduero J, Layouni T, Richardson B, Hou S, Mugo N, Mujugira A, Celum C, Baeten JM, Lingappa J, John-Stewart GC, LaCourse SM, Shah JA.J Infect Dis. 2022 May 4;225(9):1663-1674. doi: 10.1093/infdis/jiab614.PMID: 34929030 Clinical Trial.

 

Monocyte Transcriptional Responses to Mycobacterium tuberculosis Associate with Resistance to Tuberculin Skin Test and Interferon Gamma Release Assay Conversion.

Simmons JD, Dill-McFarland KA, Stein CM, Van PT, Chihota V, Ntshiqa T, Maenetje P, Peterson GJ, Benchek P, Nsereko M, Velen K, Fielding KL, Grant AD, Gottardo R, Mayanja-Kizza H, Wallis RS, Churchyard G, Boom WH, Hawn TR.mSphere. 2022 Jun 29;7(3):e0015922. doi: 10.1128/msphere.00159-22. Epub 2022 Jun 13.PMID: 35695527 

 


TB Microbiology

 

Spiropyrimidinetriones: a Class of DNA Gyrase Inhibitors with Activity against Mycobacterium tuberculosis and without Cross-Resistance to Fluoroquinolones.

Basarab GS, Ghorpade S, Gibhard L, Mueller R, Njoroge M, Peton N, Govender P, Massoudi LM, Robertson GT, Lenaerts AJ, Boshoff HI, Joerss D, Parish T, Durand-Reville TF, Perros M, Singh V, Chibale K. Antimicrob Agents Chemother. 2022 Apr 19;66(4):e0219221. doi: 10.1128/aac.02192-21. Epub 2022 Mar 10. PMID: 35266826 

 

Triazolopyrimidines Target Aerobic Respiration in Mycobacterium tuberculosis.

Shelton C, McNeil M, Allen R, Flint L, Russell D, Berube B, Korkegian A, Ovechkina Y, Parish T. Antimicrob Agents Chemother. 2022 Apr 19;66(4):e0204121. doi: 10.1128/aac.02041-21. Epub 2022 Mar 9. PMID: 35262374 

 

Identification of β-Lactams Active against Mycobacterium tuberculosis by a Consortium of Pharmaceutical Companies and Academic Institutions.

Gold B, Zhang J, Quezada LL, Roberts J, Ling Y, Wood M, Shinwari W, Goullieux L, Roubert C, Fraisse L, Bacqué E, Lagrange S, Filoche-Rommé B, Vieth M, Hipskind PA, Jungheim LN, Aubé J, Scarry SM, McDonald SL, Li K, Perkowski A, Nguyen Q, Dartois V, Zimmerman M, Olsen DB, Young K, Bonnett S, Joerss D, Parish T, Boshoff HI, Arora K, Barry CE 3rd, Guijarro L, Anca S, Rullas J, Rodríguez-Salguero B, Martínez-Martínez MS, Porras-De Francisco E, Cacho M, Barros-Aguirre D, Smith P, Berthel SJ, Nathan C, Bates RH.ACS Infect Dis. 2022 Mar 11;8(3):557-573. doi: 10.1021/acsinfecdis.1c00570. Epub 2022 Feb 22. PMID: 35192346 

 

Early alveolar macrophage response and IL-1R-dependent T cell priming determine transmissibility of Mycobacterium tuberculosis strains.

Lovey A, Verma S, Kaipilyawar V, Ribeiro-Rodrigues R, Husain S, Palaci M, Dietze R, Ma S, Morrison RD, Sherman DR, Ellner JJ, Salgame P. Nat Commun. 2022 Feb 16;13(1):884. doi: 10.1038/s41467-022-28506-2.PMID: 35173157 

 

Identification of Novel Chemical Scaffolds that Inhibit the Growth of Mycobacterium tuberculosis in Macrophages.

Ahmed S, Manning A, Flint L, Awasthi D, Ovechkina Y, Parish T. Front Pharmacol. 2022 Jan 3;12:790583. doi: 10.3389/fphar.2021.790583. eCollection 2021.PMID: 35046812 

 

Diagnostic performance of oral swabs for non-sputum based TB diagnosis in a TB/HIV endemic setting.

LaCourse SM, Seko E, Wood R, Bundi W, Ouma GS, Agaya J, Richardson BA, John-Stewart G, Wandiga S, Cangelosi GA. PLoS One. 2022 Jan 13;17(1):e0262123. doi: 10.1371/journal.pone.0262123. eCollection 2022.PMID: 35025930 


Design, synthesis and SAR of antitubercular benzylpiperazine ureas.

Satish S, Chitral R, Kori A, Sharma B, Puttur J, Khan AA, Desle D, Raikuvar K, Korkegian A, Martis EAF, Iyer KR, Coutinho EC, Parish T, Nandan S. Mol Divers. 2022 Feb;26(1):73-96. doi: 10.1007/s11030-020-10158-3. Epub 2021 Jan 1. PMID: 33385288

 

Chemical Exploration of a Highly Selective Scaffold with Activity against Intracellular Mycobacterium tuberculosis.

Njikan S, Ahmed S, Manning A, Awasthi D, Ovechkina Y, Chowdhury S, Butts A, Parish T.Microbiol Spectr. 2022 Jun 29;10(3):e0116122. doi: 10.1128/spectrum.01161-22. Epub 2022 May 25.PMID: 35612308 


TB Public Health

 

End-point definition and trial design to advance tuberculosis vaccine development.

Garcia-Basteiro AL, White RG, Tait D, Schmidt AC, Rangaka MX, Quaife M, Nemes E, Mogg R, Hill PC, Harris RC, Hanekom WA, Frick M, Fiore-Gartland A, Evans T, Dagnew AF, Churchyard G, Cobelens F, Behr MA, Hatherill M.Eur Respir Rev. 2022 Jun 7;31(164):220044. doi: 10.1183/16000617.0044-2022. Print 2022 Jun 30.PMID: 35675923 Review.